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Collinin

CAT: 0931-T38330Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T38330Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
34465-83-3
Target
Others, Antibacterial
Related Pathways
Microbiology/Virology, Others
Bioactivity
Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml) .1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a concentration of 100 μM.3 Dietary administration of collinin (0.05% w/w) reduces the number of mice with tumors and the number of tumors per mouse in a mouse model of colitis-related carcinogenesis.4
Smiles
COc1c(OC\C=C(/C)CCC=C(C)C)ccc2ccc(=O)oc12
Molecular Formula
C20H24O4
Molecular Weight
328.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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