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Ribavirin-13C5

CAT: 0931-T38297Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T38297Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1646818-35-0
Target
HCV Protease, RSV, Antibiotic
Related Pathways
Microbiology/Virology, Proteases/Proteasome
Bioactivity
Ribavirin-13C5is intended for use as an internal standard for the quantification of ribavirin by GC- or LC-MS. Ribavirin is an antiviral guanosine nucleoside analog.1,2Upon entry into cells, ribavirin is metabolized to an active triphosphate form that induces viral RNA chain termination and inhibits viral polymerases. It reduces replication in a panel of seven RNA and four DNA viruses in Vero cells (EC50s = 2-95 μg/ml) .3Ribavirin also reduces replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Vero cells (EC50= 109.5 μM) .4Aerosol administration of ribavirin (30 mg/kg) reduces mortality in a mouse model of influenza A infection.5Formulations containing ribavirin have been used in the treatment of respiratory syncytial virus (RSV), hepatitis C virus (HCV), and viral hemorrhagic fevers.
Smiles
NC(=O)c1ncn(n1)[13C@@H]1O[13C@H]([13CH2]O)[13C@@H](O)[13C@H]1O
Molecular Formula
C8H12N4O5
Molecular Weight
249.17
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
WQC81835-01Ribavirin-13C5
R1999-01Ribavirin-13C5 (1-ß-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide-13C5)
MBS6032411-01Ribavirin-13C5 (1-beta-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide-13C5)
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