(S) -AM1241

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  (S) -AM1241 binds to cannabinoid (CB) receptors and is selective for the CB2 over the CB1 receptor (Kis = 658 and >10,000 nM, respectively, in a membrane assay using human receptors) . (S) -1241 acts as an agonist at human, rat, and mouse CB2 receptors but shows greater activity at human CB2 (EC50 = 131 nM) than at rat and mouse CB2 receptors (EC50 = 785 and 2,000 nM, respectively) . Similar to the racemate AM1241 , (S) -AM1241 produces antinociception to thermal, but not mechanical, pain in rats. The pain-reducing effect of (S) -AM1241 is blocked by the CB2-specific inhibitor SR 144528 but not by either the CB1-selective inhibitor rimonabant or the opioid receptor blocker naloxone .

• Smiles:

  C(=O)(C=1C=2C(N(C[C@H]3N(C)CCCC3)C1)=CC=CC2)C4=CC(N(=O)=O)=CC=C4I

• Molecular Formula:

  C22H22IN3O3

• Molecular Weight:

  503.33

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  444912-53-2