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Platencin

CAT: 0931-T38125-01Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0931-T38125-01Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
869898-86-2
Target
Others, Antibacterial, Antibiotic
Related Pathways
Microbiology/Virology, Others
Bioactivity
Platencin is a natural, broad-spectrum Gram-positive antibiotic isolated from *S. platensis*, which is also the source of platensimycin. Platencin inhibits two key enzymes in bacterial fatty acid synthesis, β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively), unlike platensimycin which only targets FabF. The IC50 values for platencin against FabF and FabH are 1.95 and 3.91 μg/ml, respectively. It does not exhibit cross-resistance to antibiotic-resistant bacterial strains, including methicillin-resistant *S. aureus*, vancomycin-intermediate *S. aureus*, and vancomycin-resistant Enterococci. For these reasons, platencin has potential applications in fighting antibiotic-resistant bacteria.
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[H][C@@]12CC[C@]3(CC1=C)C=CC(=O)[C@@](C)(CCC(=O)Nc1c(O)ccc(C(O)=O)c1O)[C@]3([H])C2 |c:9,TLB:12:30:5.6:2.3|
Molecular Formula
C24H27NO6
Molecular Weight
425.481
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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