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Antibiotic PF 1052

CAT: 0931-T38097-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T38097-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
147317-15-5
Target
Antifungal, Others, Antibiotic, Antibacterial
Related Pathways
Others, Microbiology/Virology
Bioactivity
Antibiotic PF 1052 is a fungal metabolite originally isolated from Phoma.1,2 It is active against S. aureus, S. parvulus, and C. perfringens (MICs = 3.13, 0.78, and 0.39 μg/ml, respectively), among others.1 It inhibits neutrophil migration in a wound assay using zebrafish larvae expressing GFP-labeled neutrophils, reducing pseudopodia formation and inducing rounding of neutrophils.2 Antibiotic PF 1052 is selective for neutrophil migration over macrophage migration in zebrafish larvae. It also inhibits the migration of murine neutrophils when used at concentrations of 10 and 20 μM.
Smiles
CCC(C)C1N(C)C(=O)C(=C(O)C2C(C=CC3CC(C)CC(C)C23)C2(C)OC2C)C1=O |w:10.10,c:14|
Molecular Formula
C26H39NO4
Molecular Weight
429.601
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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