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20-hydroxy Leukotriene B4

CAT: 0931-T38087-01Size: 25 µgDry Ice: NoHazardous: No
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CAT#:0931-T38087-01Size:25 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
79516-82-8
Target
Endogenous Metabolite, Others
Related Pathways
Others, Metabolism
Bioactivity
20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM) . However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2 receptor, but does not appear to function as an agonist.
Smiles
OCCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O
Molecular Formula
C20H32O5
Molecular Weight
352.471
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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Alternative Products

CatalogName
BML-HLB004-005020-Hydroxy-leukotriene B4
MBS579882820-hydroxy Leukotriene B4
BML-LE504-0050Leukotriene E4-20,20,20-d3
MBS581586420-Carboxy-Leukotriene B4
sc-20510520-trifluoro Leukotriene B4
MBS6005806-01CYP4F3 (Cytochrome P450 4F3, CYPIVF3, Leukotriene-B(4) omega-hydroxylase 2, Leukotriene-B(4) 20-monooxygenase 2, Cytochrome P450-LTB-omega, LTB4H)
222025-01CYP4F2 (Leukotriene-B (4) omega-hydroxylase 1, CYPIVF2, Cytochrome P450 4F2, Cytochrome P450-LTB-omega, Leukotriene-B (4) 20-Monooxygenase 1) discontinued
125595CYP4F3 (Cytochrome P450 4F3, CYPIVF3, Leukotriene-B (4) omega-hydroxylase 2, Leukotriene-B (4) 20-monooxygenase 2, Cytochrome P450-LTB-omega, LTB4H)
MBS6130843-01CYP4F3 (Cytochrome P450 4F3, CYPIVF3, Leukotriene-B(4) omega-hydroxylase 2, Leukotriene-B(4) 20-monooxygenase 2, Cytochrome P450-LTB-omega, LTB4H) (AP)
125595-FITCCYP4F3 (Cytochrome P450 4F3, CYPIVF3, Leukotriene-B (4) omega-hydroxylase 2, Leukotriene-B (4) 20-monooxygenase 2, Cytochrome P450-LTB-omega, LTB4H) (FITC)

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