GM 1489

CAT: 0931-MF-0046088-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0046088-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
171347-75-4
Target
MMP|||Others
Related Pathways
Others|||Proteases/Proteasome
Bioactivity
GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 ?M for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression as well as cell invasion in AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells. Topical administration of GM 1489 (100 ?g) inhibits increases in ear thickness and epidermal hyperplasia induced by phorbol 12-myristate 13-acetate and phorbol dibutyrate (PdiBu) in mice.
Smiles
C([C@H](NC([C@H](CC(C)C)CC(O)=O)=O)C(N[C@@H](C)C1=CC=CC=C1)=O)C=2C=3C(NC2)=CC=CC3
Molecular Formula
C27H33N3O4
Molecular Weight
463.57
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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