GM 1489

• CAS Number :

  171347-75-4

• Target :

  MMP|||Others

• Related Pathways :

  Others|||Proteases/Proteasome

• Bioactivity :

  GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 ?M for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression as well as cell invasion in AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells. Topical administration of GM 1489 (100 ?g) inhibits increases in ear thickness and epidermal hyperplasia induced by phorbol 12-myristate 13-acetate and phorbol dibutyrate (PdiBu) in mice.

• Smiles :

  C([C@H](NC([C@H](CC(C)C)CC(O)=O)=O)C(N[C@@H](C)C1=CC=CC=C1)=O)C=2C=3C(NC2)=CC=CC3

• Molecular Formula :

  C27H33N3O4

• Molecular Weight :

  463.57

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C