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Pericosine A

CAT: 0931-T37594Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T37594Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
200335-68-8
Target
Topoisomerase, Others
Related Pathways
Others, DNA Damage/DNA Repair
Bioactivity
Pericosine A is a fungal metabolite that has been found inP. byssoidesand has anticancer activity.1It inhibits the growth of a variety of cancer cells, including breast, colon, lung, ovary, stomach, and prostate cell lines (GI50s = 0.05-24.55 μM) and increases survival in a P388 mouse xenograft model when administered at a dose of 25 mg/kg. Pericosine A inhibits EGFR by 40 to 70% when used at a concentration of 100 μg/ml. It also reacts with organosulfur compounds in skunk spray to form stable thioethers as odorless products.2
Smiles
COC(=O)C1=C[C@H](O)[C@H](O)[C@H](O)[C@H]1Cl |t:4|
Molecular Formula
C8H11ClO5
Molecular Weight
222.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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