Nidulin

CAT: 0931-T37560Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T37560Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

10089-10-8

Target

Others, Antifungal, Antibacterial

Related Pathways

Microbiology/Virology, Others

Bioactivity

Nidulin is a depsidone originally isolated from A. nidulans. It is active against the bacteria M. tuberculosis and M. ranoe, as well as the fungi T. tonsurans and M. audouini. It also inhibits the growth of methicillin-resistant S. aureus (MRSA; MIC = 4 μg/ml) and has larvicidal activity toward Artemia (LC50 = 2.8 μg/ml) . Nidulin is cytotoxic to MOLT-3 cells (IC50 = 21.2 μM) but not HuCCA-1, HepG2, or A549 cells (IC50s = >112.7 μM) . It inhibits aromatase with an IC50 value of 11.2 μM.

Smiles

C(=C\C)(\C)/C1=C2C(=C(C)C(OC)=C1Cl)OC(=O)C=3C(O2)=C(Cl)C(O)=C(Cl)C3C

Molecular Formula

C20H17Cl3O5

Molecular Weight

443.7

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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