Oleyl Anilide

• Target:

  Acyltransferase|||Others

• Related Pathways:

  Metabolism|||Others

• Bioactivity:

  AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol. Oleyl analide (OA) is a weak inhibitor of acylCoA:cholesterol acyltransferase (ACAT) with an IC50 of 26 ?M. OA and the related glyceride dioleoyl phenylamino propane 1,2-diol have been linked to a syndrome of eosinophilia, excessive T-cell activation, and elevated interleukin-4 (IL-4), soluble IL-2R, and IL-5. The clinical consequences are an acute pulmonary inflammatory reaction followed by chronic neuropathy, myalgia, and autoimmune connective tissue disease, generally referred to as toxic oil syndrome (TOS) . Aniline-denatured cooking oil is a source of OA associated with TOS.

• Smiles:

  N (C (CCCCCCC/C=C\CCCCCCCC) =O) C1=CC=CC=C1

• Molecular Formula:

  C24H39NO

• Molecular Weight:

  357.57

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  5429-85-6