Alamandine

• Target :

  Angiotensin-converting Enzyme (ACE) |||RAAS

• Related Pathways :

  Metabolism|||Endocrinology/Hormones

• Bioactivity :

  Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin- (1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7) . However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2) . To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effect in spontaneously hypertensive rats and cardioprotective effects. These novel findings will be helpful for developing a new understanding of the RAS, a key regulator of blood pressure and fluid balance. The heptapeptide could serve as a model peptide, e.g. in the development and evaluation of analytical methods.

• Smiles :

  CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(O)=O

• Molecular Formula :

  C40H62N12O9

• Molecular Weight :

  855.011

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1176306-10-7