Alamandine

CAT: 0931-T37496-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0931-T37496-01Size:100 mg
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CAS Number
1176306-10-7
Target
Angiotensin-converting Enzyme (ACE) |||RAAS
Related Pathways
Metabolism|||Endocrinology/Hormones
Bioactivity
Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin- (1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7) . However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2) . To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effect in spontaneously hypertensive rats and cardioprotective effects. These novel findings will be helpful for developing a new understanding of the RAS, a key regulator of blood pressure and fluid balance. The heptapeptide could serve as a model peptide, e.g. in the development and evaluation of analytical methods.
Smiles
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(O)=O
Molecular Formula
C40H62N12O9
Molecular Weight
855.011
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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