Siamycin I

• Target :

  HIV Protease|||Antibiotic

• Related Pathways :

  Microbiology/Virology|||Proteases/Proteasome

• Bioactivity :

  Siamycin I is a tricyclic peptide originally isolated from Streptomyces and has antiviral and antibacterial activities. It is active against laboratory strains and clinical isolates of HIV-1 (ED50s = 0.05-0.45 and 0.89-5.7 ?M, respectively), as well as the CBL-20 strain of HIV-2 (ED50 = 0.45 ?M), in vitro. Siamycin I inhibits HIV-induced fusion of C8166 T cells with HIV-1-infected CEM-SS cells with an ED50 value of 0.08 ?M. It is also active against B. subtilis, M. luteus, and S. aureus (MICs = 1.6-6.3 ?g/ml) . Siamycin I inhibits autophosphorylation of the E. faecalis quorum sensing kinase FsrC induced by gelatinase biosynthesis-activating pheromone (GBAP) .

• Smiles :

  [H][C@]12CSSC[C@]3([H])NC(=O)C[C@]([H])(NC(=O)[C@H](CC(N)=O)NC(=O)[C@]([H])(CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@]([H])(NC(=O)[C@H](C)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)CNC1=O)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)C(NC(=O)CNC(=O)[C@H](CC(C)C)NC3=O)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)NCC(=O)N2|@:129|

• Molecular Formula :

  C97H131N23O26S4

• Molecular Weight :

  2163.49

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  164802-68-0