FIIN-1

• Target :

  FGFR

• Related Pathways :

  Angiogenesis|||Tyrosine Kinase/Adaptors

• Purity :

  >99.99%

• Bioactivity :

  FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3, FGFR4, Flt1, Flt14, respectively.FIIN-1 inhibited FGFR1, FGFR2, FGFR3, FGFR4, with IC50 of 9.2, 6.2, 11.9 and 189 nM. FIIN-1 inhibited FGFR1, FGFR2, FGFR3 and FGFR4, with IC50s of 9.2, 6.2, 11.9 and 189 nM, respectively.

• Smiles :

  C(N1C=2C(CN(C1=O)C3=C(Cl)C(OC)=CC(OC)=C3Cl)=CN=C(NCCCCN(CC)CC)N2)C4=CC(NC(C=C)=O)=CC=C4

• Molecular Formula :

  C32H39Cl2N7O4

• Molecular Weight :

  656.6

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1256152-35-8