FIIN-1

• Target:

  FGFR

• Related Pathways:

  Angiogenesis|||Tyrosine Kinase/Adaptors

• Purity:

  >99.99%

• Bioactivity:

  FIIN-1 (FGFR irreversible inhibitor-1) is an irreversible and selective FGFR inhibitor with Kd of 2.8, 6.9, 5.4, 120, 32 and 120 nM for FGFR1, FGFR2, FGFR3, FGFR4, Flt1, Flt14, respectively.FIIN-1 inhibited FGFR1, FGFR2, FGFR3, FGFR4, with IC50 of 9.2, 6.2, 11.9 and 189 nM. FIIN-1 inhibited FGFR1, FGFR2, FGFR3 and FGFR4, with IC50s of 9.2, 6.2, 11.9 and 189 nM, respectively.

• Smiles:

  C (N1C=2C (CN (C1=O) C3=C (Cl) C (OC) =CC (OC) =C3Cl) =CN=C (NCCCCN (CC) CC) N2) C4=CC (NC (C=C) =O) =CC=C4

• Molecular Formula:

  C32H39Cl2N7O4

• Molecular Weight:

  656.6

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1256152-35-8