Reduced Haloperidol

• Target:

  Others|||Drug Metabolite

• Related Pathways:

  Metabolism|||Others

• Bioactivity:

  Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake (Kis = 21, 25, and 33 ?M, respectively, in COS-7 cells expressing the human transporters) . Reduced haloperidol (0.5 mg/kg) increases latency to paw withdrawal in mouse models of capsaicin- but not force-induced mechanical hypersensitivity.

• Smiles:

  OC(CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)c1ccc(F)cc1

• Molecular Formula:

  C21H25ClFNO2

• Molecular Weight:

  377.88

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  34104-67-1