Reduced Haloperidol

CAT: 0931-T37167-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T37167-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

34104-67-1

Target

Others, Drug Metabolite

Related Pathways

Metabolism, Others

Bioactivity

Reduced haloperidol is an active metabolite of haloperidol . It is formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors (Kis = 1.4 and 31 nM, respectively) and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake (Kis = 21, 25, and 33 μM, respectively, in COS-7 cells expressing the human transporters) . Reduced haloperidol (0.5 mg/kg) increases latency to paw withdrawal in mouse models of capsaicin- but not force-induced mechanical hypersensitivity.

Smiles

OC(CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)c1ccc(F)cc1

Molecular Formula

C21H25ClFNO2

Molecular Weight

377.88

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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