Rolapitant

• Target:

  Neurokinin receptor

• Related Pathways:

  Neuroscience|||GPCR/G Protein

• Purity:

  0.9986

• Bioactivity:

  Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP) . This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV) . The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. Compared to other NK1-receptor antagonists, rolapitant has both a more rapid onset of action and a much longer half-life.

• Smiles:

  [H][C@] (C) (OC[C@]1 (CC[C@]2 (CCC (=O) N2) CN1) c1ccccc1) c1cc (cc (c1) C (F) (F) F) C (F) (F) F

• Molecular Formula:

  C25H26F6N2O2

• Molecular Weight:

  500.48

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  552292-08-7