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Rolapitant

CAT: 0931-T3716-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T3716-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
552292-08-7
Target
Neurokinin receptor
Related Pathways
Neuroscience|||GPCR/G Protein
Purity
0.9986
Bioactivity
Rolapitant (SCH619734) Hydrochloride is the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP) . This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV) . The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. Compared to other NK1-receptor antagonists, rolapitant has both a more rapid onset of action and a much longer half-life.
Smiles
[H][C@](C)(OC[C@]1(CC[C@]2(CCC(=O)N2)CN1)c1ccccc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F
Molecular Formula
C25H26F6N2O2
Molecular Weight
500.48
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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