Methyl alpha-eleostearate

• Target:

  Others

• Related Pathways:

  Others

• Bioactivity:

  Methyl alpha-eleostearate (?-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. ?-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, ?-ESA induced apoptosis through up-regulation of GADD45, p53, and PPAR?. In DLD-1 cells supplemented with ?-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 ?M. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 ?M for different isoforms of the enzymes. ?-ESA methyl ester is a neutral, more lipid soluble form of the free acid.

• Smiles:

  CCCC\C=C\C=C\C=C/CCCCCCCC(=O)OC

• Molecular Formula:

  C19H32O2

• Molecular Weight:

  292.463

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  4175-47-7