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Methyl alpha-eleostearate

CAT: 0931-T36889-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T36889-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
4175-47-7
Target
Others
Related Pathways
Others
Bioactivity
Methyl alpha-eleostearate (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes. α-ESA methyl ester is a neutral, more lipid soluble form of the free acid.
Smiles
CCCC\C=C\C=C\C=C/CCCCCCCC(=O)OC
Molecular Formula
C19H32O2
Molecular Weight
292.463
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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