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Chromomycin A2

CAT: 0931-T36846-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T36846-01Size:1 mg
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CAS Number
6992-70-7
Target
Autophagy|||Others
Related Pathways
Others|||Autophagy
Bioactivity
Chromomycin A2 is an aureolic acid that has been found in several marine actinomycetes and has antibacterial and anticancer activities. Chromomycin A2 inhibits the growth of B. subtilis in an agar diffusion assay. It also inhibits the growth of human SGC7901 gastric cancer, HepG2 hepatocellular carcinoma, A549 lung epithelial adenocarcinoma, HCT116 colon cancer, and COC1 ovarian cancer cells, as well as human umbilical vein endothelial cells (HUVECs; IC50s = 4, 0.5, 3, 5, 5, and 8 nM, respectively) . Chromomycin A2 (30 nM) halts the cell cycle in the G0/G1 phase and increases the protein levels of LC3A and LC3B in MALME-3M melanoma cells, indicating that it induces autophagy. It also increases the levels and promoter activity of the autophagic proteins ATG7 and ATG10 and reduces cell viability to 50% in human SCC-11 squamous cell carcinoma cells when used at a concentration of 30 nM.
Smiles
[H][C@]1(C[C@@H](O)[C@@H](OC)[C@@H](C)O1)O[C@@H]1C[C@]([H])(Oc2cc3cc4C[C@@]([H])([C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H](O[C@@]5([H])C[C@@H](O[C@@]6([H])C[C@@H](O[C@@]7([H])C[C@](C)(O)[C@@H](OC(=O)C(C)C)[C@H](C)O7)[C@H](O)[C@@H](C)O6)[C@H](O)[C@@H](C)O5)C(=O)c4c(O)c3c(O)c2C)O[C@H](C)[C@@H]1OC(C)=O
Molecular Formula
C59H86O26
Molecular Weight
1211.31
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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Alternative Products

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C174-1MGChromomycin A2
BIC1009-01Chromomycin A3
HY-W040129RChromomycin A3 (Standard)
CR004-010Chromomycin A3 Streptomyces Griseus
444520Chromomycin A3 discontinued. See C5180
TBI2064-5MGChromomycin A3, DNA probe (GC-rich) ; Apoptosis inhibitor

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