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Leoidin

CAT: 0931-T36746-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T36746-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
105350-54-7
Target
Others, Antibacterial
Related Pathways
Others, Microbiology/Virology
Bioactivity
Leoidin is a depsidone originally isolated from L. gangaleoides that has antibacterial and enzyme inhibitory activities.1,2,3 It is active against the bacteria E. faecalis, H. influenzae, M. catarrhalis, S. aureus, and S. pneumoniae (MICs = 8, 32, 1, 128, and 64 μg/ml, respectively) .2 Leoidin inhibits phenylalanyl-tRNA synthetase (PheRS) isolated from P. aeruginosa (IC50 = 42 μM) . It also inhibits organic anion-transporting polypeptide 1B1 (OATP1B1) and OATP1B3 with Ki values of 0.08 and 1.84 μM, respectively, in CHO cells expressing the human transporters.3
Smiles
COC(=O)c1c(C)c2Oc3c(Cl)c(O)c(Cl)c(C)c3C(=O)Oc2c(C)c1O
Molecular Formula
C18H14Cl2O7
Molecular Weight
413.21
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
L054-1MGLeoidin

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