DMU-212

• Target :

  ERK|||Apoptosis

• Related Pathways :

  MAPK|||Apoptosis

• Purity :

  0.9986

• Bioactivity :

  DMU-212 is a methylated derivative of resveratrol with antimitotic, anti-proliferative, antioxidant, and apoptosis-promoting activities. It induces mitotic arrest, apoptosis, and activation of ERK1/2 protein and has oral activity[1][2]. DMU-212 (0.3125-40 ?M) inhibits the growth of human melanoma cells (A375, MeWo, Bro, M5) [1]. At concentrations of 30-50 ?M over 24 hours, it upregulates cell cycle inhibitors, induces apoptosis, and activates ERK in A375 cells[1]. DMU-212 also induces G2/M arrest and apoptosis in cancer cells[1]. In a xenograft model of human ovarian cancer with six-week-old SCID female mice (20-24 g), DMU-212 (50 mg/kg, administered orally three times a week for 14 days) inhibits tumor growth[2]. [1]. Vasilis Pericles Androutsopoulos, et al. Activation of ERK1/2 is required for the antimitotic activity of the resveratrol analogue 3,4,5,4'-tetramethoxystilbene (DMU-212) in human melanoma cells. Exp Dermatol. 2015 Aug;24 (8) :632-4. [2]. Hanna Piotrowska, et al. DMU-212 inhibits tumor growth in xenograft model of human ovarian cancer. Biomed Pharmacother. 2014 May;68 (4) :397-400.

• Smiles :

  COc1ccc(\C=C\c2cc(OC)c(OC)c(OC)c2)cc1

• Molecular Formula :

  C18H20O4

• Molecular Weight :

  300.35

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  134029-62-2