RegisterLogin

DMU-212

CAT: 0931-T36674-01Size: 2 mgDry Ice: NoHazardous: No
CAT#:0931-T36674-01Size:2 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
134029-62-2
Target
ERK|||Apoptosis
Related Pathways
MAPK|||Apoptosis
Purity
0.9986
Bioactivity
DMU-212 is a methylated derivative of resveratrol with antimitotic, anti-proliferative, antioxidant, and apoptosis-promoting activities. It induces mitotic arrest, apoptosis, and activation of ERK1/2 protein and has oral activity[1][2]. DMU-212 (0.3125-40 ?M) inhibits the growth of human melanoma cells (A375, MeWo, Bro, M5) [1]. At concentrations of 30-50 ?M over 24 hours, it upregulates cell cycle inhibitors, induces apoptosis, and activates ERK in A375 cells[1]. DMU-212 also induces G2/M arrest and apoptosis in cancer cells[1]. In a xenograft model of human ovarian cancer with six-week-old SCID female mice (20-24 g), DMU-212 (50 mg/kg, administered orally three times a week for 14 days) inhibits tumor growth[2]. [1]. Vasilis Pericles Androutsopoulos, et al. Activation of ERK1/2 is required for the antimitotic activity of the resveratrol analogue 3,4,5,4'-tetramethoxystilbene (DMU-212) in human melanoma cells. Exp Dermatol. 2015 Aug;24 (8) :632-4. [2]. Hanna Piotrowska, et al. DMU-212 inhibits tumor growth in xenograft model of human ovarian cancer. Biomed Pharmacother. 2014 May;68 (4) :397-400.
Smiles
COc1ccc(\C=C\c2cc(OC)c(OC)c(OC)c2)cc1
Molecular Formula
C18H20O4
Molecular Weight
300.35
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Related Products

CatalogName
T8728-01DMU-2139
T21466-01MK-212
T207415-01HLDA-212
T35259YM 212
T22987-01MK 212 hydrochloride
TSH-00416-01Poloxamer 212 (L72)
T209631-01Antibacterial agent 212
T209947-01Anticancer agent 212
T38199-01(±)-WIN 55,212 (mesylate)
T4458-01WIN 55,212-2 Mesylate

Alternative Products

CatalogName
M28078-01DMU-212
A24197-10DMU-212 10mg
A24197-5DMU-212 5mg
A24197-50DMU-212 50mg
A24197-100DMU-212 100mg
BUP07572-01DMU-2139
bs-7005C-01DMU-2105
RR212-RK4.EURoboRocker 212

Popular Products