Geranylgeranoic Acid

• Target :

  Others

• Related Pathways :

  Others

• Bioactivity :

  Geranylgeranoic acid (GGA) is an isoprenoid that has been found inS. chinensisand has anticancer activity.1It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not primary mouse hepatocytes, when used at concentrations ranging from 1 to 20 ?M. GGA (10 ?M) induces apoptosis in Huh7 cellsvialoss of the mitochondrial membrane potential and activation of interleukin-1?-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32) .2It also inhibits lysine-specific demethylase 1 (LSD1; IC50= 46.97 ?M) .3

• Smiles :

  [#6]\[#6](-[#6])=[#6]\[#6]-[#6]-[#6](-[#6])=[#6]-[#6]-[#6]-[#6](-[#6])=[#6]-[#6]-[#6]-[#6](-[#6])=[#6]-[#6](-[#8])=O|w:18.18,13.13,8.8|

• Molecular Formula :

  C20H32O2

• Molecular Weight :

  304.474

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  83807-40-3