Geranylgeranoic Acid

CAT: 0931-T36668-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T36668-01Size:1 mg

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CAS Number

83807-40-3

Target

Others

Related Pathways

Others

Bioactivity

Geranylgeranoic acid (GGA) is an isoprenoid that has been found inS. chinensisand has anticancer activity.1It induces apoptosis in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes, but not primary mouse hepatocytes, when used at concentrations ranging from 1 to 20 μM. GGA (10 μM) induces apoptosis in Huh7 cellsvialoss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32) .2It also inhibits lysine-specific demethylase 1 (LSD1; IC50= 46.97 μM) .3

Smiles

[#6]\[#6](-[#6])=[#6]\[#6]-[#6]-[#6](-[#6])=[#6]-[#6]-[#6]-[#6](-[#6])=[#6]-[#6]-[#6]-[#6](-[#6])=[#6]-[#6](-[#8])=O |w:18.18,13.13,8.8|

Molecular Formula

C20H32O2

Molecular Weight

304.474

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Geranylgeranoic Acid

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