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(3S) -hydroxy Quinidine

CAT: 0931-T36561-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0931-T36561-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
53467-23-5
Target
Others, Drug Metabolite
Related Pathways
Metabolism, Others
Bioactivity
(3S) -hydroxy Quinidine is an active quinidine metabolite. Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 being the most active enzyme in the (3S) -hydroxy quinidine formation. (3S) -hydroxy Quinidine prolongs repolarization of canine Purkinje fibers in vitro and prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-dependent manner.
Smiles
[C@H](O)(C=1C2=C(C=CC(OC)=C2)N=CC1)[C@@]3([N@@]4C[C@@](C=C)(O)[C@](C3)(CC4)[H])[H]
Molecular Formula
C20H24N2O3
Molecular Weight
340.42
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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