(3S) -hydroxy Quinidine

• Target:

  Others|||Drug Metabolite

• Related Pathways:

  Metabolism|||Others

• Bioactivity:

  (3S) -hydroxy Quinidine is an active quinidine metabolite. Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 being the most active enzyme in the (3S) -hydroxy quinidine formation. (3S) -hydroxy Quinidine prolongs repolarization of canine Purkinje fibers in vitro and prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-dependent manner.

• Smiles:

  [C@H] (O) (C=1C2=C (C=CC (OC) =C2) N=CC1) [C@@]3 ([N@@]4C[C@@] (C=C) (O) [C@] (C3) (CC4) [H]) [H]

• Molecular Formula:

  C20H24N2O3

• Molecular Weight:

  340.42

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  53467-23-5