(3S) -hydroxy Quinidine

• Target :

  Others|||Drug Metabolite

• Related Pathways :

  Metabolism|||Others

• Bioactivity :

  (3S) -hydroxy Quinidine is an active quinidine metabolite. Quinidine, an antiarrhythmic agent, undergoes rapid first-pass metabolism by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C9, CYP2E1, and CYP3A5, with CYP3A4 being the most active enzyme in the (3S) -hydroxy quinidine formation. (3S) -hydroxy Quinidine prolongs repolarization of canine Purkinje fibers in vitro and prevents ventricular fibrillation and ventricular tachycardia after coronary reperfusion in isolated rat hearts in a dose-dependent manner.

• Smiles :

  [C@H](O)(C=1C2=C(C=CC(OC)=C2)N=CC1)[C@@]3([N@@]4C[C@@](C=C)(O)[C@](C3)(CC4)[H])[H]

• Molecular Formula :

  C20H24N2O3

• Molecular Weight :

  340.42

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  53467-23-5