Extracellular Death Factor

• Target:

  Antibacterial

• Related Pathways:

  Microbiology/Virology

• Bioactivity:

  Programmed cell death in bacteria is dependent on a system of cell-to-cell communication termed quorum sensing. Extracellular death factor (EDF) is a linear pentapeptide that communicating cells produce and release, which upon reaching a sufficient concentration activates the cell death pathway in a subset of cells. It is sensitive to extreme pH, high temperatures, and other stressful conditions. At 2.5 ng/ml, EDF has been shown to facilitate mazEF-mediated cell death, significantly reducing population size in E. coli cultures.

• Smiles:

  N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O

• Molecular Formula:

  C27H36N10O10

• Molecular Weight:

  660.64

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  960129-66-2