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QD-394

CAT: 0931-T36514-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T36514-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2132411-21-1
Target
Reactive Oxygen Species|||Others
Related Pathways
Immunology/Inflammation|||NF-?B|||Others|||Metabolism
Bioactivity
QD-394 is an inducer of reactive oxygen species (ROS) production.1It induces lipid peroxidation, increases in intracellular accumulation of reactive oxygen species (ROS), and decreases in the reduced glutathione (GSH) to oxidized GSH (GSSG) ratio in MIA PaCa-2 pancreatic cancer cells when used at concentrations ranging from 0.5 to 10 ?M. QD-394 is cytotoxic to MIA PaCa-2, PANC-1, and BxPC-3 cancer cells (IC50s = 0.64, 0.34, and 0.9 ?M, respectively) . QD-394 acts synergistically with napabucasin to reduce colony formation in MIA PaCa-2 cells.
Smiles
O=C1C=2C(C(=O)C=C1NC3=CC=C(C=C3)N4CCN(C)CC4)=NC=NC2
Molecular Formula
C19H19N5O2
Molecular Weight
349.39
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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