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Becatecarin

CAT: 0931-T36485-01Size: 250 µgDry Ice: NoHazardous: No
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CAT#:0931-T36485-01Size:250 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
119673-08-4
Target
Topoisomerase, Others
Related Pathways
DNA Damage/DNA Repair, Others
Bioactivity
Becatecarin is a water-soluble, diethylaminoethyl analog of the antineoplastic antibiotic rebeccamycin. It intercalates into DNA, stabilizing the DNA-topoisomerase complex. This results in the potent catalytic inhibition of both topoisomerases I and II, initiating DNA cleavage and apoptosis. Becatecarin, alone or in combination with other compounds, has anti-cancer as well as myelosuppressive effects in vivo. It is also a transport substrate of the ATP-binding cassette (ABC) transporter ABCG2.
Smiles
CCN(CC)CCN1C(=O)c2c(C1=O)c1c3cccc(Cl)c3n([C@@H]3O[C@H](CO)[C@@H](OC)[C@H](O)[C@H]3O)c1c1[nH]c3c(Cl)cccc3c21
Molecular Formula
C33H34Cl2N4O7
Molecular Weight
669.56
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
HY-13565Becatecarin
207087-01Becatecarin (6-N-[2- (Diethylamino) ethyl]rebeccamycin, NSC 655649, BMY-27557-14, BMS-181176, XL119)

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