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Z-AEVD-FMK

CAT: 0931-T36331-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0931-T36331-01Size:500 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1135688-47-9
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
Z-AEVD-FMK (Z-Ala-Glu-Val-Asp-Fluoromethyl Ketone) is a degradable ADC linker and caspase-10 inhibitor, reducing TNF-α/butyrate-induced apoptosis, and inhibiting Gal-9-induced apoptosis.
Smiles
[C@H](C(N[C@H](C(N[C@@H](CC(OC)=O)C(CF)=O)=O)C(C)C)=O)(NC([C@@H](NC(OCC1=CC=CC=C1)=O)C)=O)CCC(OC)=O
Molecular Formula
C28H39FN4O10
Molecular Weight
610.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

Z-Aevd-fmk
CAS Number1135688-47-9
PubChem CID25108694
IUPAC Namemethyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxo-4-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]pentanoate
Molecular FormulaC28H39FN4O10
Molecular Weight610.6
XLogP1.4
Topological Polar Surface Area195
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count11
Rotatable Bond Count20
Heavy Atom Count43
Formal Charge0
Complexity987
SMILES
C[C@@H](C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
InChI
InChI=1S/C28H39FN4O10/c1-16(2)24(27(39)32-20(21(34)14-29)13-23(36)42-5)33-26(38)19(11-12-22(35)41-4)31-25(37)17(3)30-28(40)43-15-18-9-7-6-8-10-18/h6-10,16-17,19-20,24H,11-15H2,1-5H3,(H,30,40)(H,31,37)(H,32,39)(H,33,38)/t17-,19-,20-,24-/m0/s1
InChIKey
CHZRBQFKZDGMTP-CDSYHYPYSA-N
Chemical Structure
2D Structure
2D structure of Z-Aevd-fmk
CAS: 1135688-47-9
CID: 25108694
Formula: C28H39FN4O10
MW: 610.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight610.6
XLogP31.4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count11
Rotatable Bond Count20
Exact Mass610.26502162
Monoisotopic Mass610.26502162
Topological Polar Surface Area195 Ų
Heavy Atom Count43
Formal Charge0
Complexity987
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
B1162-5Z-AEVD-FMK
AB-022Z-AEVD-FMK Recombinant Protein
FMK009Caspase-10 fmk Inhibitor Z-AEVD
1112-100Caspase-10 Inhibitor AEVD-FMK
MBS655418-01Caspase 10 Inhibitor, In Vivo, 10mM, Z-AEVD-FMK (FLICE2, Mch4)
MBS655333-01Caspase 10 Inhibitor, Cell Culture, 2mM, Z-AEVD-FMK (FLICE2, Mch4)
C2088-41Caspase 10 Inhibitor, In Vivo, 10mM, Z-AEVD-FMK (FLICE2, Mch4) discontinued
FAM800-2FAM-AEVD- FMK Caspase 10 Detection Kit
C2088-40Caspase 10 Inhibitor, Cell Culture, 2mM, Z-AEVD-FMK (FLICE2, Mch4) discontinued
A1902-5.1Z-VAD-FMK

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