Termitomycamide B

CAT: 0931-MF-0092958-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0092958-01Size:5 mg
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CAS Number
1254277-89-8
Target
Others|||GPCR
Related Pathways
Others|||GPCR/G Protein|||Endocrinology/Hormones
Bioactivity
Endoplasmic reticulum (ER) stress, caused by accumulation of misfolded proteins and a disruption of calcium homeostasis, has been linked to several neuronal diseases including, Parkinson's, Alzheimer's, and prion diseases. A screen for protective activity against ER stress-dependent cell death identified termitomycamides, extracts from the fruiting bodies of T. titanicus, a notably large edible mushroom that is cultivated symbiotically in the nests of termites Termitomycamide B is a fatty acid isolated from T. titanicus that at a dose of 0.1 ?g/ml protects against ER stress-dependent cell death in Neuro2a cells induced by tunicamycin.
Smiles
C(CNC(CCCCCCC/C=C\C/C=C\CCCCC)=O)(=O)C1=CC=2C(N1)=CC=CC2
Molecular Formula
C28H40N2O2
Molecular Weight
436.63
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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