PF-8380

• Target :

  PDE

• Related Pathways :

  Metabolism

• Purity :

  0.9945

• Bioactivity :

  PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood) . It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhibiting autotaxin; reduces LPA levels both in plasma and at the site of inflammation.

• Smiles :

  Clc1cc(Cl)cc(COC(=O)N2CCN(CCC(=O)c3ccc4[nH]c(=O)oc4c3)CC2)c1

• Molecular Formula :

  C22H21Cl2N3O5

• Molecular Weight :

  478.33

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1144035-53-9