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PF-8380

CAT: 0931-T3631-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T3631-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1144035-53-9
Target
PDE
Related Pathways
Metabolism
Purity
0.9945
Bioactivity
PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood) . It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhibiting autotaxin; reduces LPA levels both in plasma and at the site of inflammation.
Smiles
Clc1cc(Cl)cc(COC(=O)N2CCN(CCC(=O)c3ccc4[nH]c(=O)oc4c3)CC2)c1
Molecular Formula
C22H21Cl2N3O5
Molecular Weight
478.33
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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