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Aspulvinone O

CAT: 0931-T36179-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T36179-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
914071-54-8
Target
Others, Reactive Oxygen Species
Related Pathways
Others, NF-κB, Immunology/Inflammation, Metabolism
Bioactivity
Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 11.6 μM) .1 Aspulvinone O inhibits aspartate transaminase 1 (GOT1; Kd = 3.32 μM) and is cytotoxic to PANC-1, AsPC-1, and SW1990 pancreatic cancer cells (IC50s = 20.54-26.8 μM) .2 It reduces the oxygen consumption rate (OCR) and induces apoptosis in SW1990 cells. Aspulvinone O (2.5 and 5 mg/kg) reduces tumor growth in an SW1990 mouse xenograft model.
Smiles
CC(C)=CCc1cc(\C=C2/OC(=O)C(=C2O)c2cc(CC=C(C)C)c(O)cc2O)ccc1O
Molecular Formula
C27H28O6
Molecular Weight
448.515
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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