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Ivosidenib

CAT: 0931-T3617-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0931-T3617-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1448347-49-6
Target
Isocitrate Dehydrogenase (IDH), Dehydrogenase
Related Pathways
Metabolism
Purity
>99.99%
Bioactivity
Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. It specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of the oncometabolite 2-hydroxyglutarate (2 hG), which may induce cellular differentiation and inhibit cellular proliferation in IDH1-expressing tumor cells.
Smiles
Fc1cncc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N
Molecular Formula
C28H22ClF3N6O3
Molecular Weight
582.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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