Ivosidenib

• Target:

  Isocitrate Dehydrogenase (IDH) |||Dehydrogenase

• Related Pathways:

  Metabolism

• Purity:

  >99.99%

• Bioactivity:

  Ivosidenib (AG-120) is an orally available inhibitor of isocitrate dehydrogenase type 1 (IDH1) with potential antineoplastic activity. It specifically inhibits a mutated form of IDH1 in the cytoplasm, preventing the formation of the oncometabolite 2-hydroxyglutarate (2 hG), which may induce cellular differentiation and inhibit cellular proliferation in IDH1-expressing tumor cells.

• Smiles:

  Fc1cncc(c1)N([C@H](C(=O)NC1CC(F)(F)C1)c1ccccc1Cl)C(=O)[C@@H]1CCC(=O)N1c1cc(ccn1)C#N

• Molecular Formula:

  C28H22ClF3N6O3

• Molecular Weight:

  582.96

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1448347-49-6