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Evofosfamide

CAT: 931-T3615-01Size: 1 mgDry Ice: NoHazardous: No
1 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
918633-87-1
Target
Apoptosis
Related Pathways
Apoptosis
Purity
0.9975
Bioactivity
Evofosfamide (TH-302) is a hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM) conjugated with 2-nitroimidazole, possessing potential antineoplastic activity. Under hypoxic conditions, typical of hypoxic tumors, the 2-nitroimidazole moiety is reduced, releasing the DNA-alkylating Br-IPM moiety, which induces intra- and inter-strand DNA crosslinks that inhibit DNA replication and cell division, potentially causing apoptosis in tumor cells. The inactive form of the prodrug remains stable under normoxic conditions, which may reduce systemic toxicity.
Smiles
Cn1c(COP(=O)(NCCBr)NCCBr)cnc1[N+]([O-])=O
Molecular Formula
C9H16Br2N5O4P
Molecular Weight
449.04
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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