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K-TMZ

CAT: 0931-T36100-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T36100-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2269482-26-8
Target
Others
Related Pathways
Others
Bioactivity
K-TMZ is a DNA alkylating agent. It increases the concentration of O6-methylated deoxyguanosine in U87 glioblastoma multiforme (GBM) cells in a concentration-dependent manner. K-TMZ reduces cell viability of GBM cell lines lacking (IC50s = 18-44 μM) or expressing O6-methylguanine DNA methyltransferase (MGMT; IC50s = 115-240 μM) . K-TMZ can cross the blood-brain barrier and increases survival in a Br23c mouse xenograft model of GBM when administered at a dose of 14.9 mg/kg.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C