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Jacaric Acid

CAT: 0931-T36099-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T36099-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
28872-28-8
Target
Others, Apoptosis
Related Pathways
Apoptosis, Others
Bioactivity
Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid . Jacaric acid induces cell cycle arrest and apoptosis in a variety of cancer cell lines (GI50 = 1-5 μM) . It increases the production of reactive oxygen species, and cytotoxicity is abolished by the antioxidant α-tocopherol, suggesting that apoptosis results from oxidative stress. Jacaric acid is metabolized in vivo to conjugated linoleic acid , which is also cytotoxic to cancer cells. Jacaric acid inhibits cyclooxygenase-1 in vitro (Ki = 1.7 μM) and, with long term feeding, decreases stearoyl-CoA desaturase expression and activity in mice.
Smiles
CCCCC\C=C/C=C/C=C\CCCCCCC(O)=O
Molecular Formula
C18H30O2
Molecular Weight
278.436
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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