S-NEPC

CAT: 0931-T36074-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T36074-01Size:1 mg
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CAS Number
147349-28-8
Target
Epoxide Hydrolase|||Others
Related Pathways
Others|||Metabolism
Bioactivity
Cytochrome P450 metabolites of arachidonic acid, such as 11 (12) -EpETrE and 14 (15) -EpETrE have been identified as endothelium derived hyperpolarizing factors with vasodilator activity. Soluble epoxide hydrolase (sEH) catalyzes the conversion of EpETrEs to the corresponding DiHETrEs thereby diminishing their activity. Inhibitors of sEH may therefore have clinical utility for treating hypertension and systemic inflammation. S-NEPC is a colorimetric substrate used to measure sEH activity. It also is a substrate for Glutathione S-transferase, microsomal epoxide hydrolase and porcine liver carboxylesterase. Hydrolysis of S-NEPC by sEH yields 4-nitrophenol which can be quantified spectrophotometrically at 405 nm. S-NEPC is adaptable for use in 96-well microwell plate readers.
Smiles
O=C(OC[C@@H]1O[C@H]1c1ccccc1)Oc1ccc(cc1)N(=O)=O
Molecular Formula
C16H13NO6
Molecular Weight
315.281
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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