Sodium dichloroacetate

• Target:

  PDK|||ROS|||Reactive Oxygen Species|||Apoptosis|||Dehydrogenase|||Na-K-Cl cotransporter

• Related Pathways:

  Membrane transporter/Ion channel|||Metabolism|||PI3K/Akt/mTOR signaling|||NF-?B|||Apoptosis|||Immunology/Inflammation

• Purity:

  0.9987

• Bioactivity:

  Sodium dichloroacetate (BCA), a specific inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50 values of 183 and 80 ?M for PDK2 and PDK4 respectively, has been shown to derepress a mitochondrial potassium-ion channel axis, trigger apoptosis in cancer cells, and inhibit tumor growth.

• Smiles:

  C(C(=O)[O-])(Cl)Cl.[Na+]

• Molecular Formula:

  C2HCl2NaO2

• Molecular Weight:

  150.92

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2156-56-1