SY-5609

• Target:

  Apoptosis|||CDK

• Related Pathways:

  Apoptosis|||Cell Cycle/Checkpoint

• Purity:

  >99.99%

• Bioactivity:

  SY-5609 (CDK7-IN-3) is a selective non-covalent CDK7 inhibitor (Kd value is 0.07 nM), with weak inhibitory activity against CDK2, CDK9 and CDK12 with IC50 values ??of 5.5, 1.9 and 1.7 ?M, respectively, and has anti-tumor activity and inhibits cell apoptosis.

• Smiles:

  C(F)(F)(F)C=1C(C=2C=3C(NC2)=C(P(C)(C)=O)C(C#N)=CC3)=NC(N[C@H]4CCC(C)(C)NC4)=NC1

• Molecular Formula:

  C23H26F3N6OP

• Molecular Weight:

  490.46

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2417302-07-7