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3-Hydroxyterphenyllin

CAT: 0931-T36000Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T36000Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
66163-76-6
Target
Others, Apoptosis
Related Pathways
Others, Apoptosis
Bioactivity
3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 μg/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 μM, respectively), as well as methicillin-resistant S. aureus (MRSA) and V. vulnificus bacteria (MIC = 31 μg/ml for both) .3 It also inhibits HIV-1 integrase in both coupled and strand transfer assays (IC50s = 2.8 and 12.1 μM, respectively) .4
Smiles
COc1cc(c(OC)c(O)c1-c1ccc(O)c(O)c1)-c1ccc(O)cc1
Molecular Formula
C20H18O6
Molecular Weight
354.35
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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