3-Hydroxyterphenyllin

• Target :

  Others|||Apoptosis

• Related Pathways :

  Others|||Apoptosis

• Bioactivity :

  3-Hydroxyterphenyllin is a p-terphenyl fungal metabolite originally isolated from A. candidus that has diverse biological activities, including antioxidant, antiproliferative, antibacterial, and antiviral properties.1,2,3,4 It has a 96% scavenging effect on 2,2-diphenyl-1-picrylhydrazyl radicals when used at a concentration of 100 ?g/ml.2 3-Hydroxyterphenyllin inhibits the growth of HeLa cervical, A549 lung, and HepG2 liver cancer cells (IC50s = 23, 36, and 32 ?M, respectively), as well as methicillin-resistant S. aureus (MRSA) and V. vulnificus bacteria (MIC = 31 ?g/ml for both) .3 It also inhibits HIV-1 integrase in both coupled and strand transfer assays (IC50s = 2.8 and 12.1 ?M, respectively) .4

• Smiles :

  COc1cc(c(OC)c(O)c1-c1ccc(O)c(O)c1)-c1ccc(O)cc1

• Molecular Formula :

  C20H18O6

• Molecular Weight :

  354.35

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  66163-76-6