Darinaparsin

CAT: 0931-T35940-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T35940-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

69819-86-9

Target

Apoptosis, Others

Related Pathways

Others, Apoptosis

Bioactivity

Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 µM) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 µM), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 µM, respectively) . [1][2] It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2/M phase. Darinaparsin decreases transcription of Gli-2, a transcription factor that mediates Sonic hedgehog signaling, when used at a concentration of 1.5 but not 3 µM. It decreases SHP1 phosphatase activity and increases ERK phosphorylation. [2] Darinaparsin reduces tumor growth in DU145 and PC3 prostate cancer mouse xenograft models when administered at a dose of 100 mg/kg every other day.[1]

Smiles

[C@@H](NC(CC[C@@H](C(O)=O)N)=O)(C(NCC(O)=O)=O)CS[As](C)C

Molecular Formula

C12H22AsN3O6S

Molecular Weight

411.31

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Alternative Products

Catalog	Name
HY-14943-01	Darinaparsin
445803-01	Darinaparsin-d5
A22529-50	Darinaparsin 50mg
A22529-10	Darinaparsin 10mg
A22529-5	Darinaparsin 5mg
A22529-100	Darinaparsin 100mg
445802	Darinaparsin-d3

Darinaparsin

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