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PB1

CAT: 0931-T35888-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T35888-01Size:1 mL - 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
188714-28-5
Target
Others, ERK
Related Pathways
Others, MAPK
Bioactivity
PB1 is a highly-effective intracellular disulfide reducing agent with notable attributes such as excellent cell permeability, the capacity to generate a substantial intracellular concentration gradient, and remarkable stability. It serves as a borane-protected TCEP (tris (2-carboxyethyl) phosphine) analogue. PB1 demonstrates the potential to enhance the survival of retinal ganglion cells following axotomy in vitro at concentrations in the nanomolar and picomolar range. Consequently, PB1 has proven instrumental in the study of neuroprotective properties[1][2][3].
Smiles
[P](CCC(OC)=O)(CCC(OC)=O)([B+3]([H-])([H-])[H-])C1=CC=CC=C1
Molecular Formula
C14H22BO4P
Molecular Weight
296.11
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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