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JK184

CAT: 0931-T3588-02Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0931-T3588-02Size:1 mL - 10 mM (in DMSO)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
315703-52-7
Target
Hedgehog/Smoothened
Related Pathways
Stem Cells, GPCR/G Protein
Purity
0.9989
Bioactivity
JK184, a potent Hedgehog (Hh) pathway inhibitor.
Smiles
CCOc1ccc(Nc2nc(cs2)-c2c(C)nc3ccccn23)cc1
Molecular Formula
C19H18N4OS
Molecular Weight
350.44
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

JK184

structure in first source

CAS Number315703-52-7
PubChem CID1069686
IUPAC NameN-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-1,3-thiazol-2-amine
Molecular FormulaC19H18N4OS
Molecular Weight350.4
XLogP5.1
Topological Polar Surface Area79.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count25
Formal Charge0
Complexity432
SMILES
CCOC1=CC=C(C=C1)NC2=NC(=CS2)C3=C(N=C4N3C=CC=C4)C
InChI
InChI=1S/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22)
InChIKey
ROYXIPOUVGDTAO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of JK184
CAS: 315703-52-7
CID: 1069686
Formula: C19H18N4OS
MW: 350.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight350.4
XLogP35.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass350.12013238
Monoisotopic Mass350.12013238
Topological Polar Surface Area79.7 Ų
Heavy Atom Count25
Formal Charge0
Complexity432
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
S6565-01JK184
bs-60087C-01JK184 --- Hedgehog Antagonist
MBS131514JK184 (JK-184; JK 184)
sc-202649Hh Signaling Antagonist VII, JK184

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