Products for Research Use Only
RegisterLogin

Emestrin

CAT: 0931-T35772-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T35772-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
97816-62-1
Target
Others, Antibacterial
Related Pathways
Others, Microbiology/Virology
Bioactivity
Emestrin, a mycotoxin originally isolated from *E. striata*, exhibits antimicrobial, immunomodulatory, and cytotoxic activities. It is effective against fungi *C. albicans* and *C. neoformans*, and bacteria *E. coli*, *S. aureus*, and methicillin-resistant *S. aureus* (MRSA; IC50s = 3.94, 0.6, 2.21, 4.55, and 2.21 μg/ml, respectively) . Emestrin acts as a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50 = 5.4 μM in a radioligand binding assay using isolated human monocytes) . At 0.1 μg/ml, it induces apoptosis in HL-60 cells and causes necrosis in heart, thymus, and liver tissues in mice at doses of 18-30 mg/kg.
Smiles
[H][C@@]12C3OC(=O)c4ccc(OC)c(Oc5cc(ccc5O)[C@H](O)C56SSC([C@H](O)C1=COC=C3)(N2C5=O)C(=O)N6C)c4
Molecular Formula
C27H22N2O10S2
Molecular Weight
598.6
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
TN10228-01Emerin
TMAB-05552-01Anti-Emerin Antibody (2U299)

Alternative Products

CatalogName
E087-1MGEmestrin

Popular Products