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Marcfortine A

CAT: 0931-T35745Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T35745Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
75731-43-0
Target
Parasite, Others
Related Pathways
Microbiology/Virology, Others
Bioactivity
Marcfortine A, an indole alkaloid originally isolated from P. roqueforti, exhibits nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM) . It effectively eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively) . Marcfortine A also dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.
Smiles
CN1C(=O)C23CCCCN2CC11CC2(C(=O)Nc4c2ccc2OC(C)(C)C=COc42)C(C)(C)C1C3
Molecular Formula
C28H35N3O4
Molecular Weight
477.605
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
454199-01Marcfortine A
M2374-75Marcfortine A (Antibiotic UK 111866)

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