Napyradiomycin A1

CAT: 0931-MF-0042121Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0042121Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
103106-24-7
Target
Others|||Antibiotic|||Antibacterial
Related Pathways
Microbiology/Virology|||Others
Bioactivity
Napyradiomycin A1is a fungal metabolite originally isolated fromC. rubraand has diverse biological activities.1,2It is active againstS. aureus, M. luteus, B. anthracis, C. bovis, andM. smegmatis (MICs = 1.56-12.5 ?g/ml) .1Napyradiomycin A1is an estrogen receptor antagonist (IC50= 4.2 ?M in rat uterine homogenates) .2It also inhibits mitochondrial NADH:ubiquinone oxidoreductase (complex I) and succinate:ubiquinone oxidoreductase (complex II) activities in bovine heart homogenates (IC50s = 20 and 9.7 ?M, respectively) .3
Smiles
[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6][C@@]12[#8]C([#6])([#6])[#6@H](Cl)-[#6][C@]1(Cl)[#6](=O)-c1c(-[#8])cc(-[#8])cc1-[#6]2=O
Molecular Formula
C25H30Cl2O5
Molecular Weight
481.41
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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BIBR1067Napyradiomycin A
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