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16F16

CAT: 0931-T35608Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T35608Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
922507-80-0
Target
Others
Related Pathways
Others
Bioactivity
16F16 is a protein disulfide isomerase (PDI) inhibitor.1It inhibits PDI reductase activity in an enzyme assay when used at concentrations ranging from 1 to 100 μg/ml.116F16 reduces PC12 cell apoptosis induced by the misfolded huntingtin protein HTTQ103. It suppresses PDI-dependent mitochondrial outer membrane permeabilization (MOMP) in isolated PC12 cell mitochondria. 16F16 (2, 3, 4, and 10 μM) reduces HTTN90Q73mutant huntingtin-induced medium spinal neuron death and MOMP in rat corticostriatal slices. It also reduces pyramidal neuron death induced by amyloid-β precursor protein (APP) in rat corticostriatal slices.
Smiles
C(OC)(=O)C1(C)C2=C(C=3C(N2)=CC=CC3)CCN1C(CCl)=O
Molecular Formula
C16H17ClN2O3
Molecular Weight
320.77
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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