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10'-Desmethoxystreptonigrin

CAT: 0931-T35607Size: 2500 μgDry Ice: NoHazardous: No
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CAT#:0931-T35607Size:2500 μg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
136803-89-9
Target
Others, Antibacterial, Antibiotic, Transferase
Related Pathways
Metabolism, Others, Microbiology/Virology
Bioactivity
10'-Desmethoxystreptonigrin is an antibiotic originally isolated from Streptomyces and a derivative of the antibiotic streptonigrin. It is active against a variety of bacteria, including S. aureus, S. faecalis, E. coli, K. pneumoniae, and P. vulgaris (MICs = 0.4, 1.6, 3.1, 3.1 and 0.4 μg/ml, respectively) . 10'-Desmethoxystreptonigrin is cytotoxic to HCT116 colon and A2780 ovarian cancer cells (IC50s = 0.004 and 0.001 μg/ml, respectively), as well as HCT116 cells resistant to etoposide and teniposide and cisplatin-resistant A2780 cells (IC50s = 0.003, 0.001, and 0.01 μg/ml, respectively) . 10'-Desmethoxystreptonigrin is also an inhibitor of p21ras farnesylation (IC50 = 21 nM) .
Smiles
COC1=C(N)C(=O)c2nc(ccc2C1=O)-c1nc(C(O)=O)c(C)c(c1N)-c1cccc(OC)c1O |c:2|
Molecular Formula
C24H20N4O7
Molecular Weight
476.445
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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