NO-Losartan A

CAT: 0931-MF-0096330-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0096330-01Size:1 mg
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CAS Number
791122-48-0
Target
RAAS|||Others
Related Pathways
Others|||Endocrinology/Hormones
Bioactivity
Angiotensin II is a hormone that plays an important role in regulating blood pressure. Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor. Losartan is a mammalian AT1 receptor antagonist with a Ki value of 5-20 nM. In humans, losartan effectively controls hypertension while protecting renal function. Nitric oxide (NO) causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium. NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.
Smiles
C(N1C(COC(=O)C2=CC(CON(=O)=O)=CC=C2)=C(Cl)N=C1CCCC)C3=CC=C(C=C3)C4=C(C=CC=C4)C=5NN=NN5
Molecular Formula
C30H28ClN7O5
Molecular Weight
602.04
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Alternative Products

CatalogName
015682Losartan α-Butyl-losartan Aldehyde Adduct (Losartan Impurity)
B1072-1000Losartan
MBS5796925NO-Losartan A

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