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Desmethylanethol trithione

CAT: 931-T3560-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
1 mL - 10 mM (in DMSO)Selected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
18274-81-2
Target
FAK|||Apoptosis|||VEGFR|||Akt
Related Pathways
Angiogenesis|||Apoptosis|||Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors
Purity
0.9841
Bioactivity
Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, Desmethylanethol trithione improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following the stroke.
Smiles
Oc1ccc(cc1)-c1cc(=S)ss1
Molecular Formula
C9H6OS3
Molecular Weight
226.34
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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