Products for Research Use Only
RegisterLogin

Desmethylanethol trithione

CAT: 0931-T3560-01Size: 1 mL - 10 mM (in DMSO)Dry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T3560-01Size:1 mL - 10 mM (in DMSO)
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
18274-81-2
Target
FAK, Apoptosis, VEGFR, Akt
Related Pathways
Angiogenesis, Apoptosis, Cytoskeletal Signaling, PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors
Purity
0.9841
Bioactivity
Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, Desmethylanethol trithione improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following the stroke.
Smiles
Oc1ccc(cc1)-c1cc(=S)ss1
Molecular Formula
C9H6OS3
Molecular Weight
226.34
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T1285-01Anethole trithione
T29015-01Trithiozine
T203854Hexamethyl-1,3,5-trithiane

Alternative Products

CatalogName
MBS579677Desmethylanethol trithione
C6709-100Anethole trithione

Popular Products