Desmethylanethol trithione

• Target :

  FAK|||Apoptosis|||VEGFR|||Akt

• Related Pathways :

  Angiogenesis|||Apoptosis|||Cytoskeletal Signaling|||PI3K/Akt/mTOR signaling|||Tyrosine Kinase/Adaptors

• Purity :

  0.9841

• Bioactivity :

  Desmethylanethol trithione (ADT-OH) is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, Desmethylanethol trithione markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, Desmethylanethol trithione improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following the stroke.

• Smiles :

  Oc1ccc(cc1)-c1cc(=S)ss1

• Molecular Formula :

  C9H6OS3

• Molecular Weight :

  226.34

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  18274-81-2