Cuspin-1

CAT: 0931-T35594-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0931-T35594-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

337932-29-3

Target

ERK, Others

Related Pathways

MAPK, Others

Bioactivity

The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA) . Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 μM. Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Raf-MEK signaling, which results in an increased rate of SMN translation.

Smiles

Cc1ccc(cc1)C(=O)c1cncc(Br)c1

Molecular Formula

C13H10BrNO

Molecular Weight

276.13

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
MNA93229-01	Cuspin 1
GTR19192016-01	Cuspin-1
217293	Cuspin-1 ((5-Bromo-3-pyridinyl) (4-methylphenyl) methanone, Survival Motor Neuron Protein Upregulator, Cuspin-1) discontinued
OF59775-01	1,1,1,1,1-Kestoheptaose
N2864-5.1	1,1,1,1-Kestohexaose
112040	1,1,1,1-Kestohexose
410417-01	1,1,1-Trichloromethanesulfonic Acid 1,1'-Anhydride
IFA69273-01	1-Iodobicyclo[1.1.1]pentane

Cuspin-1

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