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YW1128

CAT: 0931-T35547-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T35547-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2131223-64-6
Target
Others, Wnt/beta-catenin
Related Pathways
Others, Cytoskeletal Signaling, Stem Cells
Bioactivity
YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation in mice fed a high-fat diet, but not mice fed normal chow, when administered at a dose of 40 mg/kg every other day for 11 weeks.
Smiles
CC=1N(N=NC1C(NC2=NC3=C(C=C2)C=CC=C3)=O)C4=C(C)C=CC=C4
Molecular Formula
C20H17N5O
Molecular Weight
343.38
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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