HPI-1 (hydrate)

CAT: 0931-T35538-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T35538-01Size:25 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1262770-72-8

Target

Others

Related Pathways

Others

Bioactivity

HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM) .1HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, preventing cell proliferation.1

Smiles

O=C(OCCOC)C1=C(NC2=C(C(=O)CC(C=3C=CC=CC3OC)C2)C1C=4C=CC=C(O)C4)C.O

Molecular Formula

C27H31NO7

Molecular Weight

481.54

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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