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FD223

CAT: 0931-T35531-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T35531-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2050524-24-6
Target
Others, PI3K, Apoptosis
Related Pathways
PI3K/Akt/mTOR signaling, Others, Apoptosis
Bioactivity
FD223 is a potent, selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor with a marked affinity (IC50=1 nM), demonstrating notable selectivity against other isoforms (IC50s: α=51 nM, β=29 nM, γ=37 nM) . This compound effectively suppresses the proliferation of acute myeloid leukemia (AML) cell lines by inhibiting p-AKT Ser473, thereby inducing G1 phase cell cycle arrest. FD223 holds promise for leukemia research, particularly in AML[1].
Smiles
Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1cnc2[nH]ncc2c1
Molecular Formula
C17H12ClN5O2S
Molecular Weight
385.83
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Alternative Products

CatalogName
BA3246-5FD223

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